Efficacy and epigenetic interactions of novel DNA hypomethylating agent guadecitabine (SGI-110) in preclinical models of hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is a deadly malignancy characterized at the epigenetic level by global DNA hypomethylation and focal hypermethylation on the promoter of tumor suppressor genes. In most cases it develops on a background of liver steatohepatitis, fibrosis, and cirrhosis. Guadecitabine (...

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Detalhes bibliográficos
Publicado no:Epigenetics
Main Authors: Jueliger, Simone, Lyons, John, Cannito, Sara, Pata, Illar, Pata, Pille, Shkolnaya, Marianna, Lo Re, Oriana, Peyrou, Marion, Villarroya, Francesc, Pazienza, Valerio, Rappa, Francesca, Cappello, Francesco, Azab, Mohammad, Taverna, Pietro, Vinciguerra, Manlio
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5094635/
https://ncbi.nlm.nih.gov/pubmed/27646854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15592294.2016.1214781
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