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Guadecitabine (SGI‐110) priming sensitizes hepatocellular carcinoma cells to oxaliplatin

Promoter DNA hypermethylation is an important biomarker of hepatocellular carcinoma (HCC), supporting the potential utility of demethylating agents in this disease. Guadecitabine (SGI‐110) is a second‐generation hypomethylating agent formulated as a dinucleotide of decitabine and deoxyguanosine that...

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Detalhes bibliográficos
Publicado no:Mol Oncol
Main Authors: Kuang, Yuting, El-Khoueiry, Anthony, Taverna, Pietro, Ljungman, Mats, Neamati, Nouri
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528722/
https://ncbi.nlm.nih.gov/pubmed/26160429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2015.06.002
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