SGI-110: DNA Methyltransferase Inhibitor Oncolytic

SGI-110 is a second-generation hypomethylating prodrug whose active metabolite is the well-characterized drug decitabine. This novel compound is an oligonucleotide consisting of decitabine linked through a phosphodiester bond to the endogenous nucleoside deoxyguanosine. The dinucleotide configuratio...

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Publicado en:Drugs Future
Main Authors: Griffiths, E.A., Choy, G., Redkar, S., Taverna, P., Azab, M., Karpf, A.R.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4503259/
https://ncbi.nlm.nih.gov/pubmed/26190889
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