SIRT1-metabolite binding histone macroH2A1.1 protects hepatocytes against lipid accumulation

Non-alcoholic-fatty-liver-disease (NAFLD) encompasses conditions associated to fat deposition in the liver, which are generally deteriorated during the aging process. MacroH2A1, a variant of histone H2A, is a key transcriptional regulator involved in tumorigenic processes and cell senescence, and fe...

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Bibliographische Detailangaben
Hauptverfasser: Pazienza, Valerio, Borghesan, Michela, Mazza, Tommaso, Sheedfar, Fareeba, Panebianco, Concetta, Williams, Roger, Mazzoccoli, Gianluigi, Andriulli, Angelo, Nakanishi, Tomoko, Vinciguerra, Manlio
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2014
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3927808/
https://ncbi.nlm.nih.gov/pubmed/24473773
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