Histone macroH2A1.2 promotes metabolic health and leanness by inhibiting adipogenesis

BACKGROUND: Obesity has tremendous impact on the health systems. Its epigenetic bases are unclear. MacroH2A1 is a variant of histone H2A, present in two alternatively exon-spliced isoforms macroH2A1.1 and macroH2A1.2, regulating cell plasticity and proliferation, during pluripotency and tumorigenesi...

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Veröffentlicht in:Epigenetics Chromatin
Hauptverfasser: Pazienza, Valerio, Panebianco, Concetta, Rappa, Francesca, Memoli, Domenico, Borghesan, Michela, Cannito, Sara, Oji, Asami, Mazza, Giuseppe, Tamburrino, Domenico, Fusai, Giuseppe, Barone, Rosario, Bolasco, Giulia, Villarroya, Francesc, Villarroya, Joan, Hatsuzawa, Kiyotaka, Cappello, Francesco, Tarallo, Roberta, Nakanishi, Tomoko, Vinciguerra, Manlio
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2016
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5078890/
https://ncbi.nlm.nih.gov/pubmed/27800025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13072-016-0098-9
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