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Insight into the PrP(C) → PrP(Sc) conversion from the structures of antibody-bound ovine prion scrapie-susceptibility variants
Prion diseases are associated with the conversion of the α-helix rich prion protein (PrP(C)) into a β-structure-rich insoluble conformer (PrP(Sc)) that is thought to be infectious. The mechanism for the PrP(C) → PrP(Sc) conversion and its relationship with the pathological effects of prion diseases...
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| 出版年: | Proc Natl Acad Sci U S A |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2004
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC478560/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15240887/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0400014101 |
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