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Insight into the PrP(C) → PrP(Sc) conversion from the structures of antibody-bound ovine prion scrapie-susceptibility variants
Prion diseases are associated with the conversion of the α-helix rich prion protein (PrP(C)) into a β-structure-rich insoluble conformer (PrP(Sc)) that is thought to be infectious. The mechanism for the PrP(C) → PrP(Sc) conversion and its relationship with the pathological effects of prion diseases...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC478560/ https://ncbi.nlm.nih.gov/pubmed/15240887 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400014101 |
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