Intracellular acidification is required for full activation of the sweet taste receptor by miraculin

Acidification of the glycoprotein, miraculin (MCL), induces sweet taste in humans, but not in mice. The sweet taste induced by MCL is more intense when acidification occurs with weak acids as opposed to strong acids. MCL interacts with the human sweet receptor subunit hTAS1R2, but the mechanisms by...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Sanematsu, Keisuke, Kitagawa, Masayuki, Yoshida, Ryusuke, Nirasawa, Satoru, Shigemura, Noriatsu, Ninomiya, Yuzo
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4785348/
https://ncbi.nlm.nih.gov/pubmed/26960429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22807
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