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Intracellular acidification is required for full activation of the sweet taste receptor by miraculin

Acidification of the glycoprotein, miraculin (MCL), induces sweet taste in humans, but not in mice. The sweet taste induced by MCL is more intense when acidification occurs with weak acids as opposed to strong acids. MCL interacts with the human sweet receptor subunit hTAS1R2, but the mechanisms by...

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Библиографические подробности
Опубликовано в: :Sci Rep
Главные авторы: Sanematsu, Keisuke, Kitagawa, Masayuki, Yoshida, Ryusuke, Nirasawa, Satoru, Shigemura, Noriatsu, Ninomiya, Yuzo
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2016
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4785348/
https://ncbi.nlm.nih.gov/pubmed/26960429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22807
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