CXCR4 Protein Epitope Mimetic Antagonist, POL5551, Disrupts Metastasis and Enhances Chemotherapy Effect in Triple Negative Breast Cancer

The SDF-1-receptor CXCR4 has been associated with early metastasis and poorer prognosis in breast cancers, especially the most aggressive triple negative subtype. In line with previous reports, we found that tumoral CXCR4 expression in patients with locally advanced breast cancer was associated with...

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Publicat a:Mol Cancer Ther
Autors principals: Xiang, Jingyu, Hurchla, Michelle A., Fontana, Francesca, Su, Xinming, Amend, Sarah R., Esser, Alison K., Douglas, Garry J., Mudalagiriyappa, Chidananda, Luker, Kathryn E., Pluard, Timothy, Ademuyiwa, Foluso O., Romagnoli, Barbara, Tuffin, Gérald, Chevalier, Eric, Luker, Gary D., Bauer, Michael, Zimmermann, Johann, Aft, Rebecca L., Dembowsky, Klaus, Weilbaecher, Katherine N.
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4784694/
https://ncbi.nlm.nih.gov/pubmed/26269605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-15-0252
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