Polydatin Protecting Kidneys against Hemorrhagic Shock-Induced Mitochondrial Dysfunction via SIRT1 Activation and p53 Deacetylation

Objectives. To ascertain if mitochondrial dysfunction (MD) of kidney cells is present in severe hemorrhagic shock and to investigate whether polydatin (PD) can attenuate MD and its protective mechanisms. Research Design and Methods. Renal tubular epithelial cells (RTECs) from rat kidneys experiencin...

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Bibliographic Details
Published in:Oxid Med Cell Longev
Main Authors: Zeng, Zhenhua, Chen, Zhongqing, Xu, Siqi, Zhang, Qin, Wang, Xingmin, Gao, Youguang, Zhao, Ke-seng
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2016
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4783550/
https://ncbi.nlm.nih.gov/pubmed/27057271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/1737185
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