Evidence for SIRT1 Mediated HMGB1 Release From Kidney Cells in the Early Stages of Hemorrhagic Shock

BackgroundThis study is to explore the effect of SIRT1 deacetylating inactivation on organ-derived high mobility group box 1 (HMGB1) during the development of severe hemorrhagic shock (HS).MethodsHemorrhagic shock model was reproduced in rats by blood shedding and mimicked in HK-2 cells by hypoxia-r...

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Detalhes bibliográficos
Main Authors: Siqi Xu, Zhenhua Zeng, Ming Zhao, Qiaobing Huang, Youguang Gao, Xingui Dai, Jiayin Lu, Weiqing Huang, Keseng Zhao
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019-07-01
Colecção:Frontiers in Physiology
Assuntos:
HMGB1
acetylation
sirtuin 1
renal injury
polydatin
hemorrhagic shock
Acesso em linha:https://www.frontiersin.org/article/10.3389/fphys.2019.00854/full
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