Aneuploidy shortens replicative lifespan in Saccharomyces cerevisiae

Aneuploidy and aging are correlated; however, a causal link between these two phenomena has remained elusive. Here, we show that yeast disomic for a single native yeast chromosome generally have a decreased replicative lifespan. In addition, the extent of this lifespan deficit correlates with the si...

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Bibliografiske detaljer
Udgivet i:Aging Cell
Main Authors: Sunshine, Anna B., Ong, Giang T., Nickerson, Daniel P., Carr, Daniel, Murakami, Christopher J., Wasko, Brian M., Shemorry, Anna, Merz, Alexey J., Kaeberlein, Matt, Dunham, Maitreya J.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2016
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4783355/
https://ncbi.nlm.nih.gov/pubmed/26762766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12443
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