The Fitness Consequences of Aneuploidy Are Driven by Condition-Dependent Gene Effects

Aneuploidy is a hallmark of tumor cells, and yet the precise relationship between aneuploidy and a cell’s proliferative ability, or cellular fitness, has remained elusive. In this study, we have combined a detailed analysis of aneuploid clones isolated from laboratory-evolved populations of Saccharo...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS Biol
Prif Awduron: Sunshine, Anna B., Payen, Celia, Ong, Giang T., Liachko, Ivan, Tan, Kean Ming, Dunham, Maitreya J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2015
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4444335/
https://ncbi.nlm.nih.gov/pubmed/26011532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1002155
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