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Elevated Proteasome Capacity Extends Replicative Lifespan in Saccharomyces cerevisiae
Aging is characterized by the accumulation of damaged cellular macromolecules caused by declining repair and elimination pathways. An integral component employed by cells to counter toxic protein aggregates is the conserved ubiquitin/proteasome system (UPS). Previous studies have described an age-de...
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| 主要な著者: | , , , , , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Public Library of Science
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3169524/ https://ncbi.nlm.nih.gov/pubmed/21931558 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002253 |
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