Sir2 deletion prevents lifespan extension in 32 long-lived mutants

Activation of Sir2-orthologs is proposed to increase lifespan downstream of dietary restriction (DR). Here we describe an examination of the effect of 32 different lifespan-extending mutations and four methods of dietary restriction on replicative lifespan (RLS) in the short-lived sir2Δ yeast strain...

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Main Authors: Delaney, Joe R., Sutphin, George L., Dulken, Ben, Sim, Sylvia, Kim, Jin R., Robison, Brett, Schleit, Jennifer, Murakami, Christopher J., Carr, Daniel, An, Elroy H., Choi, Eunice, Chou, Annie, Fletcher, Marissa, Jelic, Monika, Liu, Bin, Lockshon, Daniel, Moller, Richard M., Pak, Diana N., Peng, Qi, Peng, Zhao J., Pham, Kim M., Sage, Michael, Solanky, Amrita, Steffen, Kristan K., Tsuchiya, Mitsuhiro, Tsuchiyama, Scott, Johnson, Simon, Raabe, Chris, Suh, Yousin, Zhou, Zhongjun, Liu, Xinguang, Kennedy, Brian K., Kaeberlein, Matt
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3215821/
https://ncbi.nlm.nih.gov/pubmed/21902802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1474-9726.2011.00742.x
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