Specific protein homeostatic functions of small heat‐shock proteins increase lifespan

During aging, oxidized, misfolded, and aggregated proteins accumulate in cells, while the capacity to deal with protein damage declines severely. To cope with the toxicity of damaged proteins, cells rely on protein quality control networks, in particular proteins belonging to the family of heat‐shoc...

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Bibliographic Details
Published in:Aging Cell
Main Authors: Vos, Michel J., Carra, Serena, Kanon, Bart, Bosveld, Floris, Klauke, Karin, Sibon, Ody C. M., Kampinga, Harm H.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2015
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4783350/
https://ncbi.nlm.nih.gov/pubmed/26705243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12422
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