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Specific protein homeostatic functions of small heat‐shock proteins increase lifespan

During aging, oxidized, misfolded, and aggregated proteins accumulate in cells, while the capacity to deal with protein damage declines severely. To cope with the toxicity of damaged proteins, cells rely on protein quality control networks, in particular proteins belonging to the family of heat‐shoc...

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Publicat a:Aging Cell
Autors principals: Vos, Michel J., Carra, Serena, Kanon, Bart, Bosveld, Floris, Klauke, Karin, Sibon, Ody C. M., Kampinga, Harm H.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4783350/
https://ncbi.nlm.nih.gov/pubmed/26705243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12422
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