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Direct observation of a 91 bp LacI-mediated, negatively supercoiled DNA loop by atomic force microscope

Escherichia coli lactose repressor (LacI), a tetrameric protein, is a paradigmatic transcriptional factor that controls the expression of lacZYA in the lac operon. It specifically binds to the O1, O2, and O3 operators of the lac promoter, forms DNA loops, and regulates transcription of the lac opero...

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Bibliografiske detaljer
Udgivet i:FEBS Lett
Main Authors: Fulcrand, Geraldine, Chapagain, Prem, Dunlap, David, Leng, Fenfei
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4783203/
https://ncbi.nlm.nih.gov/pubmed/26878689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1873-3468.12094
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