Intratumoral INF-γ triggers an antiviral state in GL261 tumor cells: a major hurdle to overcome for oncolytic vaccinia virus therapy of cancer

Oncolytic vaccinia virus (VACV) therapy is an alternative treatment option for glioblastoma multiforme. Here, we used a comparison of different tumor locations and different immunologic and genetic backgrounds to determine the replication efficacy and oncolytic potential of the VACV LIVP 1.1.1, an a...

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Detalhes bibliográficos
Publicado no:Mol Ther Oncolytics
Main Authors: Kober, Christina, Weibel, Stephanie, Rohn, Susanne, Kirscher, Lorenz, Szalay, Aladar A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4782962/
https://ncbi.nlm.nih.gov/pubmed/27119106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mto.2015.9
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