Delivery of oncolytic vaccinia virus by matched allogeneic stem cells overcomes critical innate and adaptive immune barriers

Abstract Background Previous studies have identified IFNγ as an important early barrier to oncolytic viruses including vaccinia. The existing innate and adaptive immune barriers restricting oncolytic virotherapy, however, can be overcome using autologous or allogeneic mesenchymal stem cells as carri...

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Detalhes bibliográficos
Main Authors: Dobrin D. Draganov, Antonio F. Santidrian, Ivelina Minev, Duong Nguyen, Mehmet Okyay Kilinc, Ivan Petrov, Anna Vyalkova, Elliot Lander, Mark Berman, Boris Minev, Aladar A. Szalay
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2019-03-01
Colecção:Journal of Translational Medicine
Assuntos:
Vaccinia
Cancer
Stem Cells
Oncolysis
Oncolytic virus
Virotherapy
Acesso em linha:http://link.springer.com/article/10.1186/s12967-019-1829-z
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