Microglia and astrocytes attenuate the replication of the oncolytic vaccinia virus LIVP 1.1.1 in murine GL261 gliomas by acting as vaccinia virus traps

BACKGROUND: Oncolytic virotherapy is a novel approach for the treatment of glioblastoma multiforme (GBM) which is still a fatal disease. Pathologic features of GBM are characterized by the infiltration with microglia/macrophages and a strong interaction between immune- and glioma cells. The aim of t...

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Bibliographic Details
Published in:J Transl Med
Main Authors: Kober, Christina, Rohn, Susanne, Weibel, Stephanie, Geissinger, Ulrike, Chen, Nanhai G, Szalay, Aladar A
Format: Artigo
Language:Inglês
Published: BioMed Central 2015
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4492094/
https://ncbi.nlm.nih.gov/pubmed/26149494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-015-0586-x
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