Delivery of oncolytic vaccinia virus by matched allogeneic stem cells overcomes critical innate and adaptive immune barriers

BACKGROUND: Previous studies have identified IFNγ as an important early barrier to oncolytic viruses including vaccinia. The existing innate and adaptive immune barriers restricting oncolytic virotherapy, however, can be overcome using autologous or allogeneic mesenchymal stem cells as carrier cells...

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Dades bibliogràfiques
Publicat a:J Transl Med
Autors principals: Draganov, Dobrin D., Santidrian, Antonio F., Minev, Ivelina, Nguyen, Duong, Kilinc, Mehmet Okyay, Petrov, Ivan, Vyalkova, Anna, Lander, Elliot, Berman, Mark, Minev, Boris, Szalay, Aladar A.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2019
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6437877/
https://ncbi.nlm.nih.gov/pubmed/30917829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-019-1829-z
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