First-in-human study of TK-positive oncolytic vaccinia virus delivered by adipose stromal vascular fraction cells

BACKGROUND: ACAM2000, a thymidine kinase (TK)-positive strain of vaccinia virus, is the current smallpox vaccine in the US. Preclinical testing demonstrated potent oncolytic activity of ACAM2000 against several tumor types. This Phase I clinical trial of ACAM2000 delivered by autologous adipose stro...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Minev, Boris R., Lander, Elliot, Feller, John F., Berman, Mark, Greenwood, Bernadette M., Minev, Ivelina, Santidrian, Antonio F., Nguyen, Duong, Draganov, Dobrin, Killinc, Mehmet O., Vyalkova, Anna, Kesari, Santosh, McClay, Edward, Carabulea, Gabriel, Marincola, Francesco M., Butterfield, Lisa H., Szalay, Aladar A.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6699108/
https://ncbi.nlm.nih.gov/pubmed/31426803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-019-2011-3
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