Delivery of oncolytic vaccinia virus by matched allogeneic stem cells overcomes critical innate and adaptive immune barriers

BACKGROUND: Previous studies have identified IFNγ as an important early barrier to oncolytic viruses including vaccinia. The existing innate and adaptive immune barriers restricting oncolytic virotherapy, however, can be overcome using autologous or allogeneic mesenchymal stem cells as carrier cells...

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Vydáno v:J Transl Med
Hlavní autoři: Draganov, Dobrin D., Santidrian, Antonio F., Minev, Ivelina, Nguyen, Duong, Kilinc, Mehmet Okyay, Petrov, Ivan, Vyalkova, Anna, Lander, Elliot, Berman, Mark, Minev, Boris, Szalay, Aladar A.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6437877/
https://ncbi.nlm.nih.gov/pubmed/30917829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-019-1829-z
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