Ablation of the prion protein (PrP) gene in mice prevents scrapie and facilitates production of anti-PrP antibodies.

Mice, homozygous for prion protein (PrP) gene ablation (Prn-p0/0), develop normally and remain well > 500 days after inoculation with murine scrapie prions. In contrast, wild-type mice developed scrapie < 165 days after inoculation and most Prn-p0/+ mice, heterozygous for disruption of the PrP...

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Autori principali: Prusiner, S B, Groth, D, Serban, A, Koehler, R, Foster, D, Torchia, M, Burton, D, Yang, S L, DeArmond, S J
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1993
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC47826/
https://ncbi.nlm.nih.gov/pubmed/7902565
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