Ablation of the prion protein (PrP) gene in mice prevents scrapie and facilitates production of anti-PrP antibodies.

Mice, homozygous for prion protein (PrP) gene ablation (Prn-p0/0), develop normally and remain well > 500 days after inoculation with murine scrapie prions. In contrast, wild-type mice developed scrapie < 165 days after inoculation and most Prn-p0/+ mice, heterozygous for disruption of the PrP gene,...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Prusiner, S B, Groth, D, Serban, A, Koehler, R, Foster, D, Torchia, M, Burton, D, Yang, S L, DeArmond, S J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47826/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7902565/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.22.10608
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