Ablation of the prion protein (PrP) gene in mice prevents scrapie and facilitates production of anti-PrP antibodies.

Mice, homozygous for prion protein (PrP) gene ablation (Prn-p0/0), develop normally and remain well > 500 days after inoculation with murine scrapie prions. In contrast, wild-type mice developed scrapie < 165 days after inoculation and most Prn-p0/+ mice, heterozygous for disruption of the PrP...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Prusiner, S B, Groth, D, Serban, A, Koehler, R, Foster, D, Torchia, M, Burton, D, Yang, S L, DeArmond, S J
Médium: Artigo
Jazyk:Inglês
Vydáno: 1993
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC47826/
https://ncbi.nlm.nih.gov/pubmed/7902565
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky