The impact of macrophage and microglia secreted TNFα on oncolytic HSV-1 therapy in the glioblastoma tumor microenvironment

PURPOSE: Oncolytic herpes simplex viruses [oHSV] represent a promising therapy for glioblastoma [GB], but their clinical success has been limited. Early innate immune responses to viral infection reduce oHSV replication, tumor destruction, and efficacy. Here, we characterized the antiviral effects o...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Clin Cancer Res
Prif Awduron: Meisen, W Hans, Wohleb, Eric S, Jaime-Ramirez, Alena Cristina, Bolyard, Chelsea, Yoo, Ji Young, Russell, Luke, Hardcastle, Jayson, Dubin, Samuel, Muili, Kamaldeen, Yu, Jianhua, Caligiuri, Michael, Godbout, Jonathan, Kaur, Balveen
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4780415/
https://ncbi.nlm.nih.gov/pubmed/25829396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-3118
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