VSTAT120 REDUCES THE INNATE INFLAMMATORY RESPONSE TO INFECTION AND ENHANCES ONCOLYTIC VIRAL THERAPY FOR GLIOBLASTOMA

BACKGROUND: A major barrier to oncolytic virus (OV) efficacy for the treatment of Glioblastoma is the innate immune response; this response limits virus replication and reduces tumor cell destruction. Our lab developed a novel OV, RAMBO, which expresses the anti-angiogenic fragment Vasculostatin (Vs...

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Main Authors: Kaur, Balveen, Meisen, W. Hans, Hardcastle, Jayson, Wojton, Jeffrey, Wohleb, Eric, Alvarez-Breckenridge, Christopher, Pow-anpongkul, Pete, Godbout, Jonathan
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144633/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou209.2
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