The impact of macrophage and microglia secreted TNFα on oncolytic HSV-1 therapy in the glioblastoma tumor microenvironment

PURPOSE: Oncolytic herpes simplex viruses [oHSV] represent a promising therapy for glioblastoma [GB], but their clinical success has been limited. Early innate immune responses to viral infection reduce oHSV replication, tumor destruction, and efficacy. Here, we characterized the antiviral effects o...

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Publicat a:Clin Cancer Res
Autors principals: Meisen, W Hans, Wohleb, Eric S, Jaime-Ramirez, Alena Cristina, Bolyard, Chelsea, Yoo, Ji Young, Russell, Luke, Hardcastle, Jayson, Dubin, Samuel, Muili, Kamaldeen, Yu, Jianhua, Caligiuri, Michael, Godbout, Jonathan, Kaur, Balveen
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4780415/
https://ncbi.nlm.nih.gov/pubmed/25829396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-3118
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