Bromo-deaza-SAH: a potent and selective DOT1L inhibitor

Chemical inhibition of proteins involved in chromatin-mediated signaling is an emerging strategy to control chromatin compaction with the aim to reprogram expression networks to alter disease states. Protein methyltransferases constitute one of the protein families that participate in epigenetic con...

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Udgivet i:Bioorg Med Chem
Main Authors: Yu, Wenyu, Smil, David, Li, Fengling, Tempel, Wolfram, Fedorov, Oleg, Nguyen, Kong T., Bolshan, Yuri, Al-Awar, Rima, Knapp, Stefan, Arrowsmith, Cheryl H., Vedadi, Masoud, Brown, Peter J., Schapira, Matthieu
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4780262/
https://ncbi.nlm.nih.gov/pubmed/23433670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.01.049
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