Macitentan, a dual endothelin receptor antagonist, in combination with temozolomide leads to glioblastoma regression and long-term survival in mice

PURPOSE: The objective of the study was to determine whether astrocytes and brain endothelial cells protect glioma cells from temozolomide (TMZ) through an endothelin-dependent signaling mechanism and to examine the therapeutic efficacy of the dual endothelin receptor antagonist, macitentan, in orth...

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Publicado en:Clin Cancer Res
Autores principales: Kim, Sun-Jin, Lee, Ho Jeong, Kim, Mark Seungwook, Choi, Hyun Jin, He, Junqin, Wu, Qiuyu, Aldape, Kenneth, Weinberg, Jeffrey S., Alfred Yung, W. K., Conrad, Charles A., Langley, Robert R., Lehembre, François, Regenass, Urs, Fidler, Isaiah J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4780217/
https://ncbi.nlm.nih.gov/pubmed/26106074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-3195
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