Macitentan, a dual endothelin receptor antagonist, in combination with temozolomide leads to glioblastoma regression and long-term survival in mice

PURPOSE: The objective of the study was to determine whether astrocytes and brain endothelial cells protect glioma cells from temozolomide (TMZ) through an endothelin-dependent signaling mechanism and to examine the therapeutic efficacy of the dual endothelin receptor antagonist, macitentan, in orth...

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Udgivet i:Clin Cancer Res
Main Authors: Kim, Sun-Jin, Lee, Ho Jeong, Kim, Mark Seungwook, Choi, Hyun Jin, He, Junqin, Wu, Qiuyu, Aldape, Kenneth, Weinberg, Jeffrey S., Alfred Yung, W. K., Conrad, Charles A., Langley, Robert R., Lehembre, François, Regenass, Urs, Fidler, Isaiah J.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4780217/
https://ncbi.nlm.nih.gov/pubmed/26106074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-3195
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