Treatment of experimental human breast cancer and lung cancer brain metastases in mice by macitentan, a dual antagonist of endothelin receptors, combined with paclitaxel

BACKGROUND: We recently demonstrated that brain endothelial cells and astrocytes protect cancer cells from chemotherapy through an endothelin-dependent signaling mechanism. Here, we evaluated the efficacy of macitentan, a dual endothelin receptor (ET(A)R and ET(B)R) antagonist, in the treatment of e...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Lee, Ho Jeong, Hanibuchi, Masaki, Kim, Sun-Jin, Yu, Hyunkyung, Kim, Mark Seungwook, He, Junqin, Langley, Robert R., Lehembre, François, Regenass, Urs, Fidler, Isaiah J.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2016
Fag:
Basic and Translational Investigations
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4799693/
https://ncbi.nlm.nih.gov/pubmed/26995790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/now037
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