Low Affinity Memory CD8(+) T Cells Mediate Robust Heterologous Immunity

Heterologous immunity is recognized as a significant barrier to transplant tolerance. While pathogen elicited memory T cells can have high or low affinity for cross-reactive allogeneic peptide:MHC, the role T cell receptor (TCR) affinity during heterologous immunity has not been explored. We establi...

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Vydáno v:J Immunol
Hlavní autoři: Krummey, Scott M., Martinez, Ryan J., Andargachew, Rakieb, Liu, Danya, Wagener, Maylene, Kohlmeier, Jacob E., Evavold, Brian D., Larsen, Christian P., Ford, Mandy L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4779681/
https://ncbi.nlm.nih.gov/pubmed/26864034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1500639
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