Epigenetic silencing of Th1 type chemokines shapes tumor immunity and immunotherapy

Epigenetic silencing including histone modifications and DNA methylation is an important tumorigenic mechanism(1) However, its role in cancer immunopathology and immunotherapy is poorly understood. Using ovarian cancers as our model, we found that enhancer of zeste homolog 2 (EZH2)-mediated histone...

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Detaylı Bibliyografya
Yayımlandı:Nature
Asıl Yazarlar: Peng, Dongjun, Kryczek, Ilona, Nagarsheth, Nisha, Zhao, Lili, Wei, Shuang, Wang, Weimin, Sun, Yuqing, Zhao, Ende, Vatan, Linda, Szeliga, Wojciech, Kotarski, Jan, Tarkowski, Rafał, Dou, Yali, Cho, Kathleen, Hensley-Alford, Sharon, Munkarah, Adnan, Liu, Rebecca, Zou, Weiping
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4779053/
https://ncbi.nlm.nih.gov/pubmed/26503055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature15520
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