Epigenetic silencing of Th1 type chemokines shapes tumor immunity and immunotherapy

Epigenetic silencing including histone modifications and DNA methylation is an important tumorigenic mechanism(1) However, its role in cancer immunopathology and immunotherapy is poorly understood. Using ovarian cancers as our model, we found that enhancer of zeste homolog 2 (EZH2)-mediated histone...

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Publicado no:Nature
Main Authors: Peng, Dongjun, Kryczek, Ilona, Nagarsheth, Nisha, Zhao, Lili, Wei, Shuang, Wang, Weimin, Sun, Yuqing, Zhao, Ende, Vatan, Linda, Szeliga, Wojciech, Kotarski, Jan, Tarkowski, Rafał, Dou, Yali, Cho, Kathleen, Hensley-Alford, Sharon, Munkarah, Adnan, Liu, Rebecca, Zou, Weiping
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4779053/
https://ncbi.nlm.nih.gov/pubmed/26503055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature15520
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