IL-22(+)CD4(+) T cells promote colorectal cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L

Little is known about how the immune system impacts human colorectal cancer invasiveness and stemness. Here we detected interleukin-22 (IL-22) in patient colorectal cancer tissues that was produced predominantly by CD4(+) T cells. In a mouse model, migration of these cells into the colon cancer micr...

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Detalhes bibliográficos
Main Authors: Kryczek, Ilona, Lin, Yanwei, Nagarsheth, Nisha, Peng, Dongjun, Zhao, Lili, Zhao, Ende, Vatan, Linda, Szeliga, Wojciech, Dou, Yali, Owens, Scott, Zgodzinski, Witold, Majewski, Marek, Wallner, Grzegorz, Fang, Jingyuan, Huang, Emina, Zou, Weiping
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4032366/
https://ncbi.nlm.nih.gov/pubmed/24816405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2014.03.010
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