IL-22(+)CD4(+) T cells promote colorectal cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L

Little is known about how the immune system impacts human colorectal cancer invasiveness and stemness. Here we detected interleukin-22 (IL-22) in patient colorectal cancer tissues that was produced predominantly by CD4(+) T cells. In a mouse model, migration of these cells into the colon cancer micr...

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Huvudupphovsmän: Kryczek, Ilona, Lin, Yanwei, Nagarsheth, Nisha, Peng, Dongjun, Zhao, Lili, Zhao, Ende, Vatan, Linda, Szeliga, Wojciech, Dou, Yali, Owens, Scott, Zgodzinski, Witold, Majewski, Marek, Wallner, Grzegorz, Fang, Jingyuan, Huang, Emina, Zou, Weiping
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4032366/
https://ncbi.nlm.nih.gov/pubmed/24816405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2014.03.010
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