PRC2 epigenetically silences Th1-type chemokines to suppress effector T cell trafficking in colon cancer

Infiltration of tumors with effector T cells is positively associated with therapeutic efficacy and patient survival. However, the mechanisms underlying effector T cell trafficking to the tumor microenvironment remain poorly understood in patients with colon cancer. The polycomb repressive complex 2...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Nagarsheth, Nisha, Peng, Dongjun, Kryczek, Ilona, Wu, Ke, Li, Wei, Zhao, Ende, Zhao, Lili, Wei, Shuang, Frankel, Timothy, Vatan, Linda, Szeliga, Wojciech, Dou, Yali, Owens, Scott, Marquez, Victor, Tao, Kaixiong, Huang, Emina, Wang, Guobin, Zou, Weiping
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4715964/
https://ncbi.nlm.nih.gov/pubmed/26567139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-1938
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