Effector T Cells Abrogate Stroma-Mediated Chemoresistance in Ovarian Cancer

Effector T cells and fibroblasts are major components in the tumor microenvironment. The means through which these cellular interactions affect chemoresistance is unclear. Here, we show that fibroblasts diminish nuclear accumulation of platinum in ovarian cancer cells, resulting in resistance to pla...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Wang, Weimin, Kryczek, Ilona, Dostál, Lubomír, Lin, Heng, Tan, Lijun, Zhao, Lili, Lu, Fujia, Wei, Shuang, Maj, Tomasz, Peng, Dongjun, He, Gong, Vatan, Linda, Szeliga, Wojciech, Kuick, Rork, Kotarski, Jan, Tarkowski, Rafał, Dou, Yali, Rattan, Ramandeep, Munkarah, Adnan, Liu, J. Rebecca, Zou, Weiping
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4874853/
https://ncbi.nlm.nih.gov/pubmed/27133165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.04.009
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