Effector T Cells Abrogate Stroma-Mediated Chemoresistance in Ovarian Cancer

Effector T cells and fibroblasts are major components in the tumor microenvironment. The means through which these cellular interactions affect chemoresistance is unclear. Here, we show that fibroblasts diminish nuclear accumulation of platinum in ovarian cancer cells, resulting in resistance to pla...

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Veröffentlicht in:Cell
Hauptverfasser: Wang, Weimin, Kryczek, Ilona, Dostál, Lubomír, Lin, Heng, Tan, Lijun, Zhao, Lili, Lu, Fujia, Wei, Shuang, Maj, Tomasz, Peng, Dongjun, He, Gong, Vatan, Linda, Szeliga, Wojciech, Kuick, Rork, Kotarski, Jan, Tarkowski, Rafał, Dou, Yali, Rattan, Ramandeep, Munkarah, Adnan, Liu, J. Rebecca, Zou, Weiping
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4874853/
https://ncbi.nlm.nih.gov/pubmed/27133165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.04.009
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