Romk1 Knockout Mice Do Not Produce Bartter Phenotype but Exhibit Impaired K Excretion

Romk knock-out mice show a similar phenotype to Bartter syndrome of salt wasting and dehydration due to reduced Na-K-2Cl-cotransporter activity. At least three ROMK isoforms have been identified in the kidney; however, unique functions of any of the isoforms in nephron segments are still poorly unde...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Dong, Ke, Yan, Qingshang, Lu, Ming, Wan, Laxiang, Hu, Haiyan, Guo, Junhua, Boulpaep, Emile, Wang, WenHui, Giebisch, Gerhard, Hebert, Steven C., Wang, Tong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4777858/
https://ncbi.nlm.nih.gov/pubmed/26728465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.707877
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