Small Molecular Allosteric Activator of the Sarco/Endoplasmic Reticulum Ca(2+)-ATPase (SERCA) Attenuates Diabetes and Metabolic Disorders

Dysregulation of endoplasmic reticulum (ER) Ca(2+) homeostasis triggers ER stress leading to the development of insulin resistance in obesity and diabetes. Impaired function of the sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) has emerged as a major contributor to ER stress. We pharmacologically...

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Pubblicato in:J Biol Chem
Autori principali: Kang, Soojeong, Dahl, Russell, Hsieh, Wilson, Shin, Andrew, Zsebo, Krisztina M., Buettner, Christoph, Hajjar, Roger J., Lebeche, Djamel
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2016
Soggetti:
Metabolism
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4777852/
https://ncbi.nlm.nih.gov/pubmed/26702054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.705012
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