Diminished sarco/endoplasmic reticulum Ca(2+) ATPase (SERCA) expression contributes to airway remodelling in bronchial asthma

Phenotypic modulation of airway smooth muscle (ASM) is an important feature of airway remodeling in asthma that is characterized by enhanced proliferation and secretion of pro-inflammatory chemokines. These activities are regulated by the concentration of free Ca(2+) in the cytosol ([Ca(2+)](i)). A...

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Bibliografische gegevens
Hoofdauteurs: Mahn, Katharina, Hirst, Stuart J., Ying, Sun, Holt, Mark R., Lavender, Paul, Ojo, Oluwaseun O., Siew, Leonard, Simcock, David E., McVicker, Clare G., Kanabar, Varsha, Snetkov, Vladimir A., O'Connor, Brian J., Karner, Charlotta, Cousins, David J., Macedo, Patricia, Chung, K. Fan, Corrigan, Christopher J., Ward, Jeremy P. T., Lee, Tak H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2009
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2699374/
https://ncbi.nlm.nih.gov/pubmed/19541629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0902295106
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