Diminished sarco/endoplasmic reticulum Ca(2+) ATPase (SERCA) expression contributes to airway remodelling in bronchial asthma

Phenotypic modulation of airway smooth muscle (ASM) is an important feature of airway remodeling in asthma that is characterized by enhanced proliferation and secretion of pro-inflammatory chemokines. These activities are regulated by the concentration of free Ca(2+) in the cytosol ([Ca(2+)](i)). A...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Mahn, Katharina, Hirst, Stuart J., Ying, Sun, Holt, Mark R., Lavender, Paul, Ojo, Oluwaseun O., Siew, Leonard, Simcock, David E., McVicker, Clare G., Kanabar, Varsha, Snetkov, Vladimir A., O'Connor, Brian J., Karner, Charlotta, Cousins, David J., Macedo, Patricia, Chung, K. Fan, Corrigan, Christopher J., Ward, Jeremy P. T., Lee, Tak H.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2009
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2699374/
https://ncbi.nlm.nih.gov/pubmed/19541629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0902295106
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