Diminished sarco/endoplasmic reticulum Ca(2+) ATPase (SERCA) expression contributes to airway remodelling in bronchial asthma

Phenotypic modulation of airway smooth muscle (ASM) is an important feature of airway remodeling in asthma that is characterized by enhanced proliferation and secretion of pro-inflammatory chemokines. These activities are regulated by the concentration of free Ca(2+) in the cytosol ([Ca(2+)](i)). A...

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Detaylı Bibliyografya
Asıl Yazarlar: Mahn, Katharina, Hirst, Stuart J., Ying, Sun, Holt, Mark R., Lavender, Paul, Ojo, Oluwaseun O., Siew, Leonard, Simcock, David E., McVicker, Clare G., Kanabar, Varsha, Snetkov, Vladimir A., O'Connor, Brian J., Karner, Charlotta, Cousins, David J., Macedo, Patricia, Chung, K. Fan, Corrigan, Christopher J., Ward, Jeremy P. T., Lee, Tak H.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2009
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2699374/
https://ncbi.nlm.nih.gov/pubmed/19541629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0902295106
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