Sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) activity is required for V(D)J recombination

A whole-genome CRISPR/Cas9 screen identified ATP2A2, the gene encoding the Sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) 2 protein, as being important for V(D)J recombination. SERCAs are ER transmembrane proteins that pump Ca(2+) from the cytosol into the ER lumen to maintain the ER Ca(2+) reser...

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Bibliografische gegevens
Gepubliceerd in:J Exp Med
Hoofdauteurs: Chen, Chun-Chin, Chen, Bo-Ruei, Wang, Yinan, Curman, Philip, Beilinson, Helen A., Brecht, Ryan M., Liu, Catherine C., Farrell, Ryan J., de Juan-Sanz, Jaime, Charbonnier, Louis-Marie, Kajimura, Shingo, Ryan, Timothy A., Schatz, David G., Chatila, Talal A., Wikstrom, Jakob D., Tyler, Jessica K., Sleckman, Barry P.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Rockefeller University Press 2021
Onderwerpen:
Brief Definitive Report
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8155808/
https://ncbi.nlm.nih.gov/pubmed/34033676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20201708
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