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Small Molecular Allosteric Activator of the Sarco/Endoplasmic Reticulum Ca(2+)-ATPase (SERCA) Attenuates Diabetes and Metabolic Disorders
Dysregulation of endoplasmic reticulum (ER) Ca(2+) homeostasis triggers ER stress leading to the development of insulin resistance in obesity and diabetes. Impaired function of the sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) has emerged as a major contributor to ER stress. We pharmacologically...
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| Veröffentlicht in: | J Biol Chem |
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| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4777852/ https://ncbi.nlm.nih.gov/pubmed/26702054 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.705012 |
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