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Mechanistic Insights into Hsp104 Potentiation

Potentiated variants of Hsp104, a protein disaggregase from yeast, can dissolve protein aggregates connected to neurodegenerative diseases such as Parkinson disease and amyotrophic lateral sclerosis. However, the mechanisms underlying Hsp104 potentiation remain incompletely defined. Here, we establi...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Torrente, Mariana P., Chuang, Edward, Noll, Megan M., Jackrel, Meredith E., Go, Michelle S., Shorter, James
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4777845/
https://ncbi.nlm.nih.gov/pubmed/26747608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.707976
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