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Mechanistic Insights into Hsp104 Potentiation

Potentiated variants of Hsp104, a protein disaggregase from yeast, can dissolve protein aggregates connected to neurodegenerative diseases such as Parkinson disease and amyotrophic lateral sclerosis. However, the mechanisms underlying Hsp104 potentiation remain incompletely defined. Here, we establi...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Torrente, Mariana P., Chuang, Edward, Noll, Megan M., Jackrel, Meredith E., Go, Michelle S., Shorter, James
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4777845/
https://ncbi.nlm.nih.gov/pubmed/26747608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.707976
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