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Potentiating Hsp104 activity via phosphomimetic mutations in the middle domain
Hsp104 is a hexameric AAA + ATPase and protein disaggregase found in yeast, which can be potentiated via mutations in its middle domain (MD) to counter toxic phase separation by TDP-43, FUS and α-synuclein connected to devastating neurodegenerative disorders. Subtle missense mutations in the Hsp104...
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| Publicado no: | FEMS Yeast Res |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6454557/ https://ncbi.nlm.nih.gov/pubmed/29788207 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/femsyr/foy042 |
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