Načítá se...
Potentiating Hsp104 activity via phosphomimetic mutations in the middle domain
Hsp104 is a hexameric AAA + ATPase and protein disaggregase found in yeast, which can be potentiated via mutations in its middle domain (MD) to counter toxic phase separation by TDP-43, FUS and α-synuclein connected to devastating neurodegenerative disorders. Subtle missense mutations in the Hsp104...
Uloženo v:
| Vydáno v: | FEMS Yeast Res |
|---|---|
| Hlavní autoři: | , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Oxford University Press
2018
|
| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6454557/ https://ncbi.nlm.nih.gov/pubmed/29788207 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/femsyr/foy042 |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!
|